Cydem VT System
Automated Cell Culture System
The Cydem VT Automated Cell Culture System combines multiple trusted Beckman Coulter Life Sciences technologies into one advanced platform that empowers lab managers with a far more effective, higher-throughput method for top clone screening in Cell Line Development—offering increased confidence that promising clones don’t get overlooked in the process of consistently selecting the best.
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Features of the Cydem VT Automated Cell Culture System
Combining multiple Beckman Coulter technologies into a single, standalone platform, the Cydem VT Automated Cell Culture System opens up a whole new world to hard-working lab managers and scientists, who strive daily for success in the high-pressure world of Cell Line Development. Gain more understanding from more clones from one single experiment.
Integrated Bioreactor Module
- Cultivate 96 clones in parallel in 24-deep well bioreactor plates
- Unique gassing chip for well-individual gassing control
- Maintain optimal pH and DO levels in your cultivations
Integrated Cell Count and Viability Module
- Regular updates of cell count and viability throughout your entire experiment
- Accurate and precise measurements with low sample volume
- Utilizes our well-known Vi-CELL BLU Analyzer technology
Integrated Titer Module
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Regular antibody titer measurements
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Learn more about the productivity of your clones
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Make informed decisions about your clone selection
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Small sample volume
Integrated Liquid Handler
- Automate your top clone screening
- Run more controlled fed-batch conditions and reduce the risk to select suboptimal clones
- Automated seeding and cell density normalization
- Schedule builder for analysis, fed-batch, and pH control
High Throughput
96 x 5 mL parallel microbioreactors
Optimized Selection Confidence
pH-controlled, fed-batch conditions with individual gassing regulation (CO2 & dissolved oxygen) in each parallel microbioreactor
Early Insights
Regular on-deck cell count, viability and titer measurements throughout the entire cultivation
Full Automation
Less manual work and human error;
reduced risk of contamination
3-Day Walk-Away Automated Operation with Auto-Normalization of Cell Density
- Fully integrated solution with on-deck cell count, cell viability, mAbs titer, pH, and DO measurement
- 3-day walk-away automated operation
- Automated seeding of cell cultures
- Schedule builder for analytical measurements, feeding strategy, and pH control
- Centralized data on one instrument with the ability to easily export in .csv format
- Single point of contact for sales, service, and technical support for the entire system, consumables, and reagents
Clone screening of 96 clones over 14 days. Viable cell density and mAbs titer displayed over the course of the experiment. For a better overview, 10 clones with different growth and productivity performances were selected.
Resources
Introducing the Cydem VT Automated Cell Culture System: A high-throughput platform for fast and reliable clone screening experiments
Efficient clone screening with increased process control and integrated cell health and titer measurements with the Cydem VT Automated Clone Screening System
Reagents and Consumables
Human IgG Standard Kit, 10 mg
The Human IgG Standard Kit contains 10 mg human IgG standard for measuring a monoclonal antibody (mAb) standard curve with the Cydem VT system.
Cydem VT System Cell Health Test Kit
The Cell Health Test Kit contains reagents (Trypan Blue, Cleaning Solution, Cell Health Diluent) for a minimum of 6 x 96 cell health tests. It is recommended if more cell count and viability measurements are required than are included in the regular Cell Culture Standard Experiment Kit.
Cydem VT System Cell Culture Standard Experiment Kit
The Cell Culture Standard Experiment Kit contains all cell health reagents and bioreactor plates required for a standard 2-week campaign: Contains a kit with four 24-well bioreactor plates and two Cell Health Test Kits with reagents (Trypan Blue, Cleaning Solution, Cell Health Diluent) for a minimum of 12 x 96 cell health tests (cell count & viability).
Product is not intended or validated for use in the diagnosis of disease or other conditions.
Cydem VT System IgG Titer Standard Experiment Kit
The IgG Titer Standard Experiment Kit contains all reagents and titer plates required for a 2-week standard campaign: Contains two Titer Test Kits, a Human IgG Standard Kit, 10 mg, and Titer Diluent for a minimum of 8 x 96 antibody titer tests.
Product is not intended or validated for use in the diagnosis of disease or other conditions.
Cydem VT System IgG Titer Extended Experiment Kit
The IgG Titer Extended Experiment Kit contains all reagents and titer plates required for a 2-week extended campaign and can run more titer tests than the standard kit: Contains three Titer Test Kits, a Human IgG Standard Kit, 10 mg, and Titer Diluent for a minimum of 12 x 96 antibody titer tests.
Product is not intended or validated for use in the diagnosis of disease or other conditions.
| Specifications | Description |
|---|---|
| Combined size (instrument + workstation cart)I |
• Width: 183 cm (72 in.) • Depth: 82 cm (32 in.) • Height: 228 cm (89.5 in.) with door closed • Height: 233 cm (91.5 in.) with door open |
| Instrument sizeI |
• Width: 170 cm (67 in.) • Depth: 82 cm (32 in.) • Height: 142 cm (56 in.) with door closed • Height: 147 cm (58 in.) with door open |
| Workstation cart size2 | • Width: 183 cm (72 in.) • Depth: 82 cm (32 in.) • Height: 85 cm (33.5 in.) |
| Weight | • Combined weight: 567 kg (1250 lbs) • Instrument only: 340 kg (750 lbs) • Workstation cart only: 227 kg (500 lbs) |
I Including HEPA filter
2 Workstation cart is always included in the Cydem VT system
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Front View 
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Side View 
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Front View Open 
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Frequently Asked Questions
The Cydem VT system supports the shaken cultivation of Chinese Hamster Ovary (CHO) cells.
The Cydem VT system allows for a pH-controlled fed-batch cultivation for 96 clones, with well-specific gassing control for pH (CO2) and dissolved oxygen (DO) control. The liquid handler can add liquid base for additional pH control.
The Cydem VT Automated Cell Culture System can screen up to 96 clones in parallel shaken 5 mL microtiter plate format.
The Cydem VT system uses Valita Titer Assay technology and can quantify all Fc-containing molecules (e.g., IgG-based antibodies IgG 1, 2, 3, and 4 subclasses, standard, bispecific, fusion protein formats, etc.).
You can find all technical documentation here.
The working volume is in a range of 3-5 mL.
The system provides regular on-deck measurements of pH and dissolved oxygen (DO) values, monoclonal antibody (mAb) titer, and cell count and viability.
Technical Documents