CD154 Antigen

The CD154 antigen (CD40-ligand), also known as TRAP (Tumor necrosis factor Related Activation Protein), is a member of the Tumor Necrosis Factor (TNF) superfamily. It is a 32 kDa type II transmembrane molecule. CD154 is rapidly induced on T cells (CD4+ and some CD8+ cells) following TCR activation. First identified on activated T cells, CD154 is also expressed on platelets, as well as monocytes and B cells. CD154 can also be shed from activated platelets and lymphocytes in a soluble form (sCD154). This ligand for the CD40 molecule is present on some basophils and mast cells. It has critical regulatory roles in T- and B-lymphocyte function. CD40/CD154 interaction is essential for the development of thymus-dependent humoral immune responses. Ligation of CD40 on B cells by CD154 on T cells promotes B cell proliferation, immunoglobulin (Ig) production, isotype switching and memory B-cell generation.


 Clone: TRAP-1  Isotype: IgG1 Mouse

The TRAP-1 antibody inhibits activation induced by full-length soluble human CD154.
 

 

Explore Beckman Coulter CD154 Conjugated Antibodies

Part Number Product Name Status Clone Size List Price Buy
ASR
TRAP-1
2 mL

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Product Line Specifications

Format Liquid
Specificity CD154
Form PE
Clone TRAP-1
Isotype IgG1 Mouse
Cross Reactivity Cynomolgus Monkey, Hamadyras Baboon, Indian Rhesus, Olive Baboon
Target Species Human
Flow Product Line IOTest
Item Specifications Referenced IM2216U

The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent. 


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