CD196 (CCR6) Antigen

CD196, also known as CCR6, is G-proteincoupled receptor (GPCR) consisting of an extracellular amino terminal, seven membrane-spanning regions and a cytoplasmic carboxyl terminal. CCR6 is a member of the beta chemokine receptor. CD196 is a 374 amino acids long protein and has a calculated molecular weight of 42 kDa. CD196 is predominantly expressed by B lymphocytes, certain subsets of effector and memory T cells and by immature dendritic cells but not by monocytes, NK cells or granulocytes. CD196 binds CCL20, although members of the β defensin family (family of anti-bacterial peptides) also bind CD196 with a lower affinity. CD196 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both healthy and diseased skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of inflammatory joints diseases and inflammatory bowel diseases. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.

 Clone: B-R35  Isotype: IgG2a Mouse

The B-R35 monoclonal antibody specifically binds to CCR6.


Explore Beckman Coulter CD196 (CCR6) Conjugated Antibodies

Part Number Product Name Status Clone Size List Price Buy
0.5 mL


Product Line Specifications

Format Liquid
Specificity CD196
Form PC7
Clone B-R35
Isotype IgG2a Mouse
Target Species Human
Flow Product Line IOTest
Item Specifications Referenced B68132

The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent. 

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