DAP12 (DNAX / KARAP / TYROBP) Antigen

The DAP12 antigen (DNAX activating protein of 12 kDa) is a type I transmembrane glycoprotein which is also known as KARAP (killer cell activating receptor-associated protein) or TYROBP (tyrosine kinase binding protein). It is encoded by a gene located on the chromosome 19q13 and contains an intracytoplasmic immunoreceptor tyrosine-based activation motif (ITAM). The DAP12 antigen associates with a large family of receptors in hematopoietic cells conferring to this antigen a broad range of intracellular signaling functions Interestingly, it has been shown to both potentiate or inhibit leukocytes activation. When associated with KIRs (stimulatory killer Ig-like receptors), the adaptor molecule DAP12 functions as an activation unit leading to the T cell activation. It has also been shown that the activation of the syk/ZAP70 tyrosine kinases by DAP12 plays a role in the stimulation of NK cells and T cells. On the contrary, the DAP12 association with other receptors such as Fc receptor γ-chain and CD3ζ may lead to the regulation of T cell immune response.


 Clone: H10E12F4   Isotype: IgG1 Rat

The H10E12F4 monoclonal antibody recognizes monocytes, neutrophils, dendritic cells, NK cells and to a lesser extend basophils, and B lymphocytes. It does not recognize CD4 and CD8 T cells or B cells.
 

 

Explore Beckman Coulter DAP12 (DNAX / KARAP / TYROBP) Conjugated Antibodies

Part Number Product Name Status Clone Size List Price Buy
RUO
H10E12F4
100 Tests

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Product Line Specifications

Format Liquid
Specificity DAP12
Form PE
Clone H10E12F4
Isotype IgG1 Rat
Target Species Human
Flow Product Line IOTest
Item Specifications Referenced A78886

The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent. 


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